Ēthrane: Proceeding of the First European Symposium on by Von P. Lawin (auth.), P. Lawin, R. Beer, E. Wiethoff (eds.)

By Von P. Lawin (auth.), P. Lawin, R. Beer, E. Wiethoff (eds.)

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Extra resources for Ēthrane: Proceeding of the First European Symposium on Modern Anesthetic Agents Hamburg, November, 9th and 10th, 1973

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3, durchgezogene Linie). -% Ethrane ist der Cytochrom-P450 -Gehalt gegenuber den Kontrollen unverandert (Abb. -% Ethrane am dritten Tag ein minimaler Zuwachs an Cytochrom P450 zu beobachten ist (Abb. 3, gepunktete Linie). (5x3Std) + 20 ..... , .. / .............. _ -------------'' '<::--.. , 3 5 KontroUen ...... 7 Tage nach Exposition Abb. 3. Prozentuale Anderung von Cytochrom P 450 in der Leber weiblicher Ratten vor und nach Vorbehandlung mit Ethrane und Halothan, n = 6 - 8 bei Versuchs- und Kontrolltieren - 48 Demgegenuber ist die Aktivitat der NADPH-Cytochrom-c-Reduktase sowohl nach Halothan als auch nach Ethrane gesteigert (Abb.

0074 From the analysis of KETY (~) the value of k equals the ratio between tissue blood flow per unit volume and the tissue-blood partition coefficient: tissue blood flow k = tissue volume x tissue-blood partition coefficient Each experimental value of k has been obtained for Halothane and Ethrane in the same patient, that is, at the same value of tissue blood flow per unit volume. Consequently, any difference between the k values of - 23 - Halothane and Ethrane for the same compartment must necessarily reflect a difference in the anesthetic tissue-blood partition coefficient.

ZugefUhrt wird (Abb. 4, gestrichelte und gepunktete Linie). Abb. -% Halothan bzw. Athylmorphin. Athylmorphin urn 71 %. Athylmorphin in vitro urn 23 % gesteigert. _ -'- -. --~"--"-------"-"-"-"-"-"-"o • Ethrane 2,5 V01%(5x3Std) c I:thrane 2,5Vol%(5xlStd) O~------------------------~~--- 3 5 KontroUen 7 Tage nach Exposition Abb. 4. Anderung der NADPH-Cytochrom-c-Reduktaseaktivitat der Leber weiblicher Ratten vor und"nach Vorbehandlung mit Ethrane bzw. Halothan, n = 6 - 8 bei Versuchs- und Kontrolltieren - 49 - Entsprechend verhalt sich das arzneimitteloxydierende System (Abb.

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