By William Slikker Jr., David S Lester, William Slikker Jr, Philip Lazarovici
This designated quantity presents interdisciplinary insurance of the mechanistic viewpoint of neurotoxicity that specializes in the location of motion of identified neurotoxins. It presents the reader with an perception into the typical features of neurotoxin motion at the worried process and examines websites of motion at 3 degrees of complexity: molecular, mobile, and mind, with a view to let the advance of extra particular healing and pharmacological rationales for therapy sooner or later. Site-Selective Neurotoxicity comprises worthy details for graduate scholars and educational and commercial researchers within the fields of toxicology, pharmacology, neurosciences and medicine.
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This detailed quantity presents interdisciplinary insurance of the mechanistic point of view of neurotoxicity that specializes in the positioning of motion of identified neurotoxins. It presents the reader with an perception into the typical features of neurotoxin motion at the anxious procedure and examines websites of motion at 3 degrees of complexity: molecular, mobile, and mind, so as to permit the improvement of extra particular healing and pharmacological rationales for therapy sooner or later.
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Additional info for Site-Selective Neurotoxicity (Cellular and Molecular Mechanisms of Toxic Action)
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In the 16 rats, that were only torpid after AMPH and 3-NPA, the neurotoxicity was similar to that produced by AMPH alone. , 1995). Therefore, combined exposure to 3-NPA and AMPH produced 3-NPA type neurotoxicity in half the survivors, while the remaining survivors exhibited an AMPH-like neurotoxicity. , 1996). There is compelling evidence that the neurotoxicity of AMPH and METH could involve energy depletion. , 1979; Rutledge, 1978). It is suggested that when high concentrations of AMPH are present the uptake transporters may be running at such an increased rate as to reduce energy/ATP supplies via excess consumption.