Site-Selective Neurotoxicity (Cellular and Molecular by William Slikker Jr., David S Lester, William Slikker Jr,

By William Slikker Jr., David S Lester, William Slikker Jr, Philip Lazarovici

This designated quantity presents interdisciplinary insurance of the mechanistic viewpoint of neurotoxicity that specializes in the location of motion of identified neurotoxins. It presents the reader with an perception into the typical features of neurotoxin motion at the worried process and examines websites of motion at 3 degrees of complexity: molecular, mobile, and mind, with a view to let the advance of extra particular healing and pharmacological rationales for therapy sooner or later. Site-Selective Neurotoxicity comprises worthy details for graduate scholars and educational and commercial researchers within the fields of toxicology, pharmacology, neurosciences and medicine.

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O. Amdur, J. Doull and C. D. ), Toxicology: The Basic Science of Poisons, Pergamon, New York, pp. 407–429. Benet, L. , Mitchell, J. R. and Sheiner, L. B. (1990). Pharmacokinetics: the dynamics of drug absorption, distribution and elimination. In A. A. Gilman, T. W. Rall, A. Nies and P. ), The Pharmacological Basis of Therapeutics, Pergamon, New York, pp. 3–32. Brierly, J. B. and Graham, D. I. (1984) Hypoxia and vascular disorders of the central nervous system. In J. H. Adams, J. A. N. Corsellis and L.

14, 2260–2271. Dzoljic, E. , Kaplan, C. D. and Dzoljic, M. R. (1988) Effect of ibogaine on naloxone precipitated withdrawal syndrome in chronic morphine dependent rats. Arch. Int. , 294, 64–70. Eisch, A. , Weihmuller, F. , O’Dell, S. J. and Marshall, J. F. (1992) Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine. , 598, 321–326. Ellison, G. (1992) Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus.

In the 16 rats, that were only torpid after AMPH and 3-NPA, the neurotoxicity was similar to that produced by AMPH alone. , 1995). Therefore, combined exposure to 3-NPA and AMPH produced 3-NPA type neurotoxicity in half the survivors, while the remaining survivors exhibited an AMPH-like neurotoxicity. , 1996). There is compelling evidence that the neurotoxicity of AMPH and METH could involve energy depletion. , 1979; Rutledge, 1978). It is suggested that when high concentrations of AMPH are present the uptake transporters may be running at such an increased rate as to reduce energy/ATP supplies via excess consumption.

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