Principles and Applications of Magnetic Particle Imaging by Bernhard Gleich

By Bernhard Gleich

Bernhard Gleich introduces Magnetic Particle Imaging (MPI) together with all facets which are invaluable for a whole realizing. MPI is a brand new imaging modality invented via Bernhard Gleich and Jürgen Weizenecker. the strategy is in a position to imaging the distribution of superparamagnetic iron oxide debris (SPIOs) with excessive sensitivity, excessive spatial answer, and excessive imaging velocity. the writer summarizes the result of a couple of unique papers and numerous options he has elaborated within the younger self-discipline of magnetic particle imaging.

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Replacing v by the angular rotation frequency ω we get: F = π ωηD2 2 Therefore, the torque on the particle is T = π ωηD3 4 This torque has to be balanced by the magnetic torque which is at maximum: πD3 MV H = MH T = μ0 4μ0 Here M is the magnetization of the material, H the external magnetic field and V the cylinder’s volume, which can be expressed in terms of D. Combining the two equations and solving for ω we get: ω= μ0 M H η So the rotation speed is independent of the size of the particle. Setting M and H to 1 Tμ−1 0 and η to 1 mPa s, which is approximately the viscosity of water, the rotation speed is ω ≈ 2π·100 MHz.

As a consequence, the amount of magnetic material has to be diluted in a 54 Chapter 6. Resolution, sensitivity and speed voxel. Assuming a voxel size of 1 mm3 , the detectable local concentration is 13 nmol(Fe)/l. For voxel of a size of 1 cm3 , the detection limit is 13 pmol(Fe)/l. 4 Detection limit of MRI To give these numbers meaning, they have to be compared to other imaging modalities. The detection limit of magnetic resonance imaging depends in a complicated way on the experimental setting.

So it is possible to measure all voxels simultaneously. The noise bandwidth per voxel is still the 2 Blood clearance is usually fast, but intracellular decay time constants vary from days to month depending on the type of coating 58 Chapter 6. 2: Encoding mechanisms in magnetic resonance imaging (MRI) and MPI. Two regions of magnetization in opposite directions are separated by a moving and rotation line/plane. 3. Encoding efficiency 59 inverse of the measuring time, so in the frequency encoded images, all voxels have a quality as if each voxel was measured the total measuring time individually.

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