Behçet's Disease: From Genetics to Therapies by Yoshiaki Ishigatsubo

By Yoshiaki Ishigatsubo

This ebook, in addition to reviewing easy and scientific facets of Behçet's sickness, covers the newest findings, together with genetic experiences and therapy with biologics for the illness.
Although the reason for Behçet's affliction continues to be unknown, it truly is renowned that genetic components, resembling HLA-B51, are excited about its improvement. lately, novel susceptibility loci together with IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 were pointed out, delivering new insights into the pathogenesis of the illness. as well as uncomplicated learn, the priceless efficacy of anti-TNF-alpha monoclonal antibodies has additionally been prompt for not just uveitis linked to the sickness but in addition different subtypes of the sickness resembling entero-, vasculo-, and neuro- Behçet's sickness. Behçet's sickness: From Genetics to Therapies presents crucial info either for uncomplicated researchers operating within the fields of immunology, irritation, and genetics, and for medical physicians who're attracted to Behçet's illness, corresponding to ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​

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Extra info for Behçet's Disease: From Genetics to Therapies

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Immune responses against microbes and microbial antigens play an important role in the pathogenesis of BD. Regional differences of the disease distribution [12] suggested association of disease development with locally prevalent microbes. Oral health was often impaired in patients with BD and was correlated well with BD disease severity [13]. Streptococcus sanguinis is a commensal oral bacterium and often forms dental plaque. S. sanguinis was found frequently in oral flora in patients with BD, and the strain showed uncommon serotype (KTH1) compared with the standard ATCC strains [14].

2 The Immunopathology of Behçet’s Disease 39 106. Ringel-Kulka T, Cheng J, Ringel Y, et al. S. young children and adults – a high throughput microarray analysis. PLoS One. 2013;8(5):e64315. 0064315. 107. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104:13780–5. Chapter 3 Genetics Akira Meguro and Nobuhisa Mizuki Abstract The etiology of Behçet’s disease (BD) is still unclear, but currently some external environmental factors are thought to trigger BD in individuals with a particular genetic background.

J Rheumatol. 1994;21:2301–6. 93. Hasan A, Fortune F, Wilson A, et al. Role of gamma delta T cells in pathogenesis and diagnosis of Behcet’s disease. Lancet. 1996;347:789–94. 94. Yamashita N, Kaneoka H, Kaneko S, et al. Role of gammadelta T lymphocytes in the development of Behçet’s disease. Clin Exp Immunol. 1997;107:241–7. 95. Mochizuki M, Suzuki N, Takeno M, et al. Fine antigen specificity of human gamma delta T cell lines (V gamma 9+) established by repetitive stimulation with a serotype (KTH-1) of a gram-positive bacterium, Streptococcus sanguis.

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